Deltamycins, new macrolide antibiotics. III. Chemical structures.
نویسندگان
چکیده
منابع مشابه
New streptothricin-group antibiotics, AN-201 I, II and III. II. Chemical structures.
The new, belonging to the streptothricin-group antibiotics AN-201 I, II and III were found to be produced by a soil actinomycete identified as Streptomyces nojiriensis C-13. The chemical structures and the physical and spectroscopic properties of these compounds are reported here. On the basis of NMR and fast atom bombardment mass spectrometry (FAB-MS) spectra the antibiotics were identified as...
متن کاملMycinamicins, new macrolide antibiotics. VIII. Chemical degradation and absolute configuration of mycinamicins.
Mycinamicins, a new family of basic 16membered macrolide antibiotics were produced by Micromonospora griseorubida sp. nov. They consist of at least seven components, named as mycinamicin I (1), 11 (2), III (3), IV (4), V (5), VI (6) and VII (7), and possess strong antibacterial activity against Gram-positive bacteria1-4). In an earlier study, the structures and stereochemistry of mycinamicins w...
متن کاملThe polyene macrolide antibiotics.
The mode of action of the polyene antibiotics is reviewed together with the effect of genetic and environmental factors on sensitive organisms. The future prospects of polyenes in the treatment of systemic mycoses are considered.
متن کاملChimeramycins: new macrolide antibiotics produced by hybrid biosynthesis.
Sir: Microbial conversion of antibiotically inactive macrocyclic lactones to active compounds is an important approach in the search for new macrolide antibiotics. Mutational biosynthesis originally proposed by SHIER et al.1) was proved useful also for constructing new macrolide antibiotics and many new derivatives were obtained. However, these were virtually inactive,2-1) or weakly active and ...
متن کاملNew directions for macrolide antibiotics: pharmacokinetics and clinical efficacy.
Erythromycin and related macrolide antibiotics have recently enjoyed a resurgence of clinical interest. This is a result of activity against organisms which are becoming more prevalent, particularly in immunocompromised hosts and, in addition, better understanding of the unique tissue penetration properties and potential immunomodulating properties of macrolides. Other features of clinical inte...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Journal of Antibiotics
سال: 1979
ISSN: 0021-8820,1881-1469
DOI: 10.7164/antibiotics.32.878